Efficacy in pressure sore repair in spinal-cord injured patients


Assess the efficacy of VULNAMIN gel in wound healing. Pressure injuries in patients with spinal cord injuries become chronic due to local and general causes. The compromise between ulcer status and the needs of everyday life determine continuous pressure and delayed healing.


  • 10 patients were recruited who agreed to give our laboratory a biopsy.
  • 3 biopsies were taken from each patient at 0, 7 and 15 days after the application of Vulnamin.


  • histological study on surgically excised chronic pressure sores was carried out . The results in this case were extremely indicative for a hypoxic tissue with different types of local treatment.
  • Histological changes were evaluated in the first 15 days correlated to clinical improvement of granulation tissue.


Reduction of Hypoxia Inducible Factors

Ido factor

Significant positivity of the IDO factors

Reduction of deposit of iron and increase in tranferrin receptors

  • Increase in the vascular component
  • The increase of vessels in the granulation tissue already seen at the 7th day and a progressive increase at the 15th day
  • Increase in the fibroblastic quota and the collagen component

Action of topical amino-acid mixtures in chronic pressure sore repair in spinal-cord injured patients


  • Histological changes were evident with immuno-histochemical methods.
  • A new angiogenesis, persistence of macrophage components and a significant population of fibroblasts with increased collagen deposition.
Other Clinical Evidence

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